{"id":1677,"date":"2021-12-08T12:56:45","date_gmt":"2021-12-08T12:56:45","guid":{"rendered":"https:\/\/lam.unitedforclinicalnutrition.com\/pt-br\/?p=1677"},"modified":"2022-06-01T10:25:57","modified_gmt":"2022-06-01T13:25:57","slug":"molibdenio-na-nutricao-parenteral","status":"publish","type":"post","link":"https:\/\/lam.unitedforclinicalnutrition.com\/pt-br\/molibdenio-na-nutricao-parenteral\/","title":{"rendered":"O molibd\u00eanio e sua import\u00e2ncia para a nutri\u00e7\u00e3o parenteral"},"content":{"rendered":"

\"\"<\/p>\n

 <\/p>\n

Um oligoelemento conhecido h\u00e1 pouco tempo \u00e9 o molibd\u00eanio. Apesar disso, ele \u00e9 considerado um nutriente essencial<\/strong> por estar diretamente relacionado ao bom funcionamento de algumas prote\u00ednas<\/strong> que atuam em processos bioqu\u00edmicos importantes do corpo humano, como veremos mais adiante.<\/p>\n

Esse mineral est\u00e1 presente na maioria das frutas e verduras<\/strong>, sendo naturalmente ingerido pelas pessoas que consomem alimentos in natura por via oral regularmente1<\/sup>. Pessoas que recebem alimenta\u00e7\u00e3o por via intravenosa, entretanto, dependem de uma composi\u00e7\u00e3o de macro e micronutrientes equilibrada. Por isso, h\u00e1 f\u00f3rmulas dedicadas a pacientes em alimenta\u00e7\u00e3o parenteral<\/a> total que incluem o molibd\u00eanio em baixas doses.<\/p>\n

Papel do molibd\u00eanio<\/h2>\n

Mesmo hoje sendo considerado um elemento tra\u00e7o, a import\u00e2ncia do moibd\u00eanio s\u00f3 foi evidenciada na d\u00e9cada de 1950. Ele passou a ser considerado um oligoelemento essencial quando se descobriu que participava de processos importantes do metabolismo humano.2<\/sup><\/p>\n

Normalmente, o molibd\u00eanio encontra-se ligado a prote\u00ednas tanto no sangue quanto em tecidos<\/strong>1<\/strong><\/sup>.<\/strong> As maiores concentra\u00e7\u00f5es do mineral s\u00e3o encontradas no f\u00edgado, nos rins e na gl\u00e2ndula suprarrenal, e as menores, na pele, no es\u00f4fago, na traqueia, na aorta, no \u00fatero e na bexiga2<\/sup>.<\/p>\n

Sabe-se que o molibd\u00eanio atua como cofator de pelo menos quatro enzimas.2<\/sup> Confira a seguir:<\/p>\n

Sulfito oxidase<\/h3>\n

A sulfito oxidase catalisa a rea\u00e7\u00e3o terminal na degrada\u00e7\u00e3o dos amino\u00e1cidos sulfurados. A defici\u00eancia gen\u00e9tica da sulfito oxidase resulta em anormalidades neurol\u00f3gicas e frequentemente leva \u00e0 morte em idade precoce.2,3<\/sup><\/p>\n

Xantina oxidase<\/h3>\n

A xantina oxidase catalisa a oxida\u00e7\u00e3o de purinas em \u00e1cido \u00farico.2 <\/sup>Ela est\u00e1 presente no leite e em muitos outros tecidos e vem sendo estudada h\u00e1 mais de 100 anos, sendo que sua complexidade estrutural e distribui\u00e7\u00e3o de tecidos especializados sugerem outras fun\u00e7\u00f5es que nunca foram totalmente identificadas, como a capacidade de gerar esp\u00e9cies reativas de oxig\u00eanio e \u00f3xido n\u00edtrico.4<\/sup><\/p>\n

Alde\u00eddo oxidase<\/h3>\n

A alde\u00eddo oxidase est\u00e1 envolvida no metabolismo de v\u00e1rios\u00a0compostos\u00a0N-heteroc\u00edclicos\u00a0end\u00f3genos e ex\u00f3genos de import\u00e2ncia farmacol\u00f3gica e toxicol\u00f3gica. Essa enzima \u00e9 o produto de um gene que est\u00e1 implicado na etiopatog\u00eanese da esclerose lateral amiotr\u00f3fica recessiva familiar.5<\/sup><\/p>\n

Amidoxima mitocondrial<\/h3>\n

O componente redutor de amidoxima mitocondrial (mARC) foi descoberto recentemente. Est\u00e1 presente de forma abundante no f\u00edgado e nos rins e acredita-se que partcipa da desintoxica\u00e7\u00e3o de substratos N-hidroxilados.2<\/sup><\/p>\n

Defici\u00eancia de molibd\u00eanio<\/h2>\n

Como vimos, o molibd\u00eanio \u00e9 necess\u00e1rio para diversas fun\u00e7\u00f5es do organismo. A eventual falta desse nutriente pode levar ao preju\u00edzo da atividade das enzimas <\/strong>que dependem desse metal como cofator6<\/sup>.<\/p>\n

A defici\u00eancia de molibd\u00eanio, no entanto, \u00e9 rara, j\u00e1 que ele est\u00e1 presente em diversos alimentos. Por\u00e9m, ela j\u00e1 foi observada em paciente submetido \u00e0 nutri\u00e7\u00e3o parenteral total prolongada para o tratamento de doen\u00e7a de Crohn, que apresentou sinais cl\u00ednicos como irritabilidade, taquicardia, taquipneia (respira\u00e7\u00e3o acelerada) e cegueira noturna.7<\/sup><\/p>\n

Os sintomas da defici\u00eancia no mineral podem ocorrer com maior frequ\u00eancia em beb\u00eas. Nesse caso, eles apresentam uma anomalia gen\u00e9tica que os impede de sintetizar o molibd\u00eanio, levando \u00e0 falta da enzima sulfito oxidase. Como consequ\u00eancia, podem surgir danos neurol\u00f3gicos graves, convuls\u00f5es e morte dos rec\u00e9m-nascidos poucos dias ap\u00f3s o parto.6<\/sup><\/p>\n

\n

Leia tamb\u00e9m:<\/b> O que \u00e9 desnutri\u00e7\u00e3o relacionada a doen\u00e7a?<\/a><\/p>\n

\n

Gostou desse artigo? <\/strong>Leia mais sobre Nutri\u00e7\u00e3o Parenteral aqui.<\/strong><\/a><\/p>\n

Refer\u00eancias<\/h3>\n
    \n
  1. Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press; 2001. Dispon\u00edvel em: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK222301\/<\/a><\/li>\n
  2. Novotny JA. Molybdenum nutriture in humans<\/em>. J Evid Based Compl Alter Med 2011;16(3):164-8. Dispon\u00edvel em: https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/2156587211406732<\/a><\/li>\n
  3. GARRET, R.M. et al. Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme<\/em>. Proc Natl Acad Sci USA. 1998;95(11):6394-8. Dispon\u00edvel em: https:\/\/pubmed.ncbi.nlm.nih.gov\/9600976\/<\/a><\/li>\n
  4. HARRISON, R. Structure and function of xanthine oxidoreductase: where are we now?<\/em> Free Radic Biol Med. 2002;33(6):774-97. Dispon\u00edvel em: https:\/\/pubmed.ncbi.nlm.nih.gov\/12208366\/<\/a><\/li>\n
  5. TERAO, M. et al. Isolation and characterization of the human aldehyde oxidase gene: Conservation of intron\/exon boundaries with the xanthine oxidoreductase gene indicates a common origin<\/em>. Biochemical Journal 1998;332 ( Pt 2)(Pt 2):383-93. Dispon\u00edvel em: https:\/\/www.researchgate.net\/publication\/13683259_Isolation_and_characterization_of_the_human_aldehyde_oxidase_gene_Conservation_of_intronexon_boundaries_with_the_xanthine_oxidoreductase_gene_indicates_a_common_origin<\/li>\n
  6. Arnold GL, Greene CL, Stout JP, Goodman SI. Molybdenum cofactor deficiency. J Pediatr 1993;123(4):595-8. Dispon\u00edvel em: https:\/\/www.jpeds.com\/article\/S0022-3476(05)80961-8\/pdf<\/a><\/li>\n
  7. Abumrad NN. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdenum therapy. Am J Clin Nutr 1981;34(11):2551-9. Dispon\u00edvel em: https:\/\/academic.oup.com\/ajcn\/article-abstract\/34\/11\/2551\/4692819?redirectedFrom=fulltext<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Um oligoelemento conhecido h\u00e1 pouco tempo \u00e9 o molibd\u00eanio. Apesar disso, ele \u00e9 considerado um nutriente essencial por estar diretamente relacionado ao bom funcionamento de algumas prote\u00ednas que atuam em processos bioqu\u00edmicos importantes do corpo humano, como veremos mais adiante. Esse mineral est\u00e1 presente na maioria das frutas e verduras, sendo naturalmente ingerido pelas […]<\/p>\n","protected":false},"author":1,"featured_media":1736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[49,9],"tags":[125,80,67,85],"class_list":["post-1677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artigo-5","category-nutricao-parenteral","tag-molibdenio","tag-npt","tag-nutricao-parenteral","tag-oligoelementos"],"acf":[],"yoast_head":"\nConhe\u00e7a o molibd\u00eanio e sua import\u00e2ncia para a nutri\u00e7\u00e3o parenteral<\/title>\n<meta name=\"description\" content=\"O molibd\u00eanio \u00e9 um oligoelemento que participa de rea\u00e7\u00f5es importantes do metabolismo. 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